Deep brain stimulation in drug-resistant epilepsy:current status and future perspectives
HU Tian-qi
XIE Hu-tao
ZHANG Jian-guo
Abstract：Drug-resistant epilepsy remains a major challenge in management of epilepsy,with approximately half of patients being unsuitable candidates for resective surgery.In recent years,deep brain stimulation(DBS),as a neuromodulation therapy,has demonstrated promising potential.This review summarizes recent advances in DBS for drug-resistant epilepsy,focusing on major stimulation targets and their associated neurophysiological mechanisms.We also discuss the suitability of various DBS targets for different epilepsy types and provide perspectives on future directions,including individualized adjustment of stimulation parameters and the development of closed-loop stimulation,aiming to inform clinical practice and guide further research in the management of drug-resistant epilepsy.
Keywords：Drug resistant epilepsyDeep brain stimulationSubthalamic nucleusPulvinarIntralaminar thalamic nucleiHippocampusReview
Publication Date：2026-01-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：8( 57-64 )