Clinical progress of neuromodulation therapy for spinocerebellar ataxia type 3
WANG Cheng-en
LI Xue-hui
GENG Zi-han
ZHAO Fei
YANG Jia-jia
Abstract：Spinocerebellar ataxia type 3(SCA3)is an autosomal dominant neurodegenerative disease,with core clinical symptoms including motor disorders and cognitive impairment.Since there is currently no effective radical treatment,the development of targeted diagnostic strategies and intervention measures to delay disease progression is particularly urgent.In recent years,neuromodulation technique has attracted widespread attention as an emerging therapeutic strategy for neurological diseases;they achieve therapeutic goals by precisely adjusting stimulation parameters to act on specific brain regions.This article aims to systematically discuss the existing efficacy studies of three neuromodulation techniques,including non-invasive techniques such as repetitive transcranial magnetic stimulation(rTMS),transcranial electrical stimulation(TES),and invasive technique such as deep brain stimulation(DBS),in the clinical application of SCA3,and explore the application potential of neuromodulation technique such as transcranial focused ultrasound stimulation(tFUS)and optogenetics in the field of SCA3 treatment.It is expected to provide new ideas and references for the in-depth research and clinical transformation of neuromodulation technique in SCA3.
Keywords：Machado-Joseph diseaseTranscranial magnetic stimulationElectric stimulation therapyDeep brain stimulationUltrasonic therapyOptogeneticsReview
Publication Date：2026-01-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：10( 40-49 )