The modification and application precautions of the WHO classification of tumors of the central nervous system(fifth edition)
YU Shi-zhu
SUN Cui-yun
Abstract：The fifth edition of the WHO classification of tumors of the central nervous system(CNS5,2021)is based on the concept of precision medicine.CNS5 incorporates a large number of new molecular diagnostic indicators as well as more detailed clinical and molecular epidemiological follow-up data.Through this,CNS5 has formulated new schemes for reclassifying,sub-classifying,typing,sub-typing,grading,and/or renaming of CNS tumors,and also added a large number of new tumor entities,significantly improving the accuracy,reproducibility,and consistency of diagnosis.This article briefly describes the main modification and significance of CNS5 and the precautions for its application.
Keywords：Central nervous system neoplasmsWorld Health OrganizationThe fifth edition(not in MeSH)
Publication Date：2026-01-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：7( 1-7 )