Autoimmune cerebellar ataxia associated with anti-seizure related 6 homolog like 2 antibody:one case report and literature review
BI Zhua-jin
KANG Wen-zhong
ZHANG Li
JIANG Yan
WANG Qun
CHEN Min
Abstract：Objective Autoimmune cerebellar ataxia associated with anti-seizure related 6 homolog like 2(SEZ6L2)antibody was reported,with the literature review and summary clinical features and treatment.Methods and Results The patient was a 59-year-old female hospitaled in The First Affiliated Hospital of Zhengzhou University in July 2025,with progressive unsteady gait as the main clinical manifestation with dysarthria and mild cognitive dysfunction.Cell based assay(CBA)showed the titer of anti-SEZ6L2 antibody in serum was 1∶320,and cerebrospinal fluid was 1∶10.MRI showed cerebellar hemisphere and vermis mildly atrophy.The therapeutic effect of hormonotherapy was not good.After adding Efgartigimod α to eliminate pathogenic antibodies,the patient received sequential low-dose methylprednisolone therapy combined with mycophenolate mofetil for 3 months.The symptom was improved and could walk with unilateral assistance.Conclusions Cerebellar ataxia was one of the clinical features of anti-SEZ6L2 antibody-associated disease,is associated with a poor prognosis.Efgartigimod α can be used as a treatment option to improve the prognosis of patients.
Keywords：Autoimmune diseasesCerebellar ataxiaAutoantibodiesCerebrospinal fluidSEZ6L2(not in MeSH)
Publication Date：2025-12-25
Online Publishing Date：2026-01-23(First online date of this platform, not the publication date of the document)
Pages：6( 1157-1162 )