Relationship between sepsis-associated encephalopathy and nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and progress of traditional Chinese medicine treatment
CHEN Yue
LIU Xue-hua
Abstract：Sepsis-associated encephalopathy(SAE)is a serious complication of sepsis leading to neurological dysfunction.The pathogenesis of sepsis-associated encephalopathy is complex,and studies have proved that it is closely related to neuroinflammation,oxidative stress,pyroptosis,blood-brain barrier disruption,etc..Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,a multiprotein complex mediating inflammatory response and participating in innate immunity,is involved in occurence and developing of sepsis-associated encephalopathy.The activation of NLRP3 inflammasome is associated with apoptosis,pyroptosis,ferroptosi and autophagy.Traditional Chinese medicine plays a role in preventing and treating sepsis-associated encephalopathy,and studies have found that traditional Chinese medicine intervention significantly inhibits the activation of NLRP3 inflammasome.This article discusses the relationship between NLRP3 inflammasome and sepsis-associated encephalopathy.It reviews the potential and promise of traditional Chinese medicine targeting NLRP3 inflammasome as a treatment for the corresponding conditions,to provide valuable references and assistance for future sepsis-associated encephalopathy treatment strategies.
Keywords：Sepsis-associated encephalopathyNLR familypyrin domain-containing 3 proteinInflammationPhytotherapyReview
Publication Date：2025-11-25
Online Publishing Date：2025-12-16(First online date of this platform, not the publication date of the document)
Pages：6( 1077-1082 )