Analysis of visuo-oculomotor dysfunction and risk factors for dizziness in Parkinson's disease patients
LENG Ying-lin
REN Lu
ZHOU Hong
WANG Xia
ZHAO Gui-ping
SUN Yun-chuang
Abstract：Objective To summarize the visuo-oculomotor dysfunction in Parkinson's disease(PD)patients with dizziness,and to analyze the risk factors for dizziness.Methods A total of 80 patients with PD visiting Peking University First Hospital between January 2019 and October 2022 were enrolled and divided into dizziness group(n=35)and non-dizziness group(n=45)based on the presence or absence of dizziness complaints within one month prior to enrollment.Subjective dizziness severity was assessed using the Visual Analog Scales(VAS)and the Dizziness Handicap Inventory(DHI)for patients with dizziness.All patients underwent video-nystagmography(VNG)examinations,including without-fixation test,fixation test,reflexive saccade test,memory-guided saccade test,smooth pursuit test and optokinetic test,to obtain visuo-oculomotor function related parameters.Univariate and multivariate linear regression analyses were used to analyze influencing factors for DHI score.Univariate and multivariate Logistic regression analyses were used to screen influencing factors for dizziness in PD patients.Subgroups analysis of clinical characteristics and visuo-oculomotor function related parameters was performed based on the presence or absence of neurogenic orthostatic hypotension(nOH)in dizziness group.Results Multivariate linear regression analysis showed that the presence of nOH(standardized partial regression coefficient=0.385,P=0.031)and the average saccade latency(standardized partial regression coefficient=0.400,P=0.028)had positive influences on the DHI score.The presence of nOH(OR=4.701,95%CI:1.398-15.806;P=0.012)and a prolonged average saccade latency(OR=1.013,95%CI:1.002-1.025;P=0.022)were risk factors for dizziness in PD patients.Patients in the dizziness group were further divided into 2 subgroups based on the presence of nOH:subgroup without nOH(n=20)and subgroup with nOH(n=15).Compared to the subgroup without nOH,the subgroup with nOH had a higher proportion of obstructive sleep apnea-hypopnea syndrome(OSAHS,Fisher's exact probability:P=0.032),and shorter average saccade latencies at 10°(t=2.147,P=0.039)and 25°(t=2.698,P=0.011)targets.Conclusions The complication of nOH and prolonged average saccade latency are risk factors for dizziness in PD patients and increase the severity of dizziness.PD patients with dizziness are prone to manifest sleep disorders such as rapid eye movement sleep behavior disorder(RBD)and OSAHS.
Keywords：Parkinson diseaseDizzinessEye movement measurementsSaccadesHypotensionorthostaticSleep disordersRisk factorsLogistic modelsRegression analysis
Publication Date：2025-11-25
Online Publishing Date：2025-12-16(First online date of this platform, not the publication date of the document)
Pages：9( 1060-1068 )