Risk factors for epilepsy recurrence in anti-N-methyl-D-aspartate receptor encephalitis patients with epileptic seizure
WANG Xue
LIU Xiao
WANG Qun
Abstract：Objective To investigate the risk factors for epilepsy recurrence in anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis patients with epileptic seizure.Methods A total of 78 anti-NMDAR encephalitis patients with epileptic seizure admitted to Beijing Tiantan Hospital,Capital Medical University from August 2013 to September 2022 were included.Clinical data of the patients were analyzed,and epilepsy recurrence was observed during follow-up period.According to whether epilepsy recurrence occurred during the follow-up period,the patients were divided into epilepsy recurrence group(n=18)and epilepsy non-recurrence group(n=60).Univariate and multivariate Logistic regression analyses were used to screen risk factors for epilepsy recurrence in anti-NMDAR encephalitis patients with epileptic seizure.Results During(2.21±0.45)years'follow-up,18 cases(23.08%)experienced epilepsy recurrence.Multivariate Logistic regression analysis showed that combined tumors(OR=24.154,95%CI:2.597-224.640;P=0.005),cognitive impairment(OR=7.809,95%CI:1.338-45.557;P=0.022),and cortical lesions on MRI(OR=9.868,95%CI:1.223-79.620;P=0.032)were risk factors for epilepsy recurrence in anti-NMDAR encephalitis patients with epileptic seizure.Conclusions Combined tumors,cognitive impairment,and cortical lesions on MRI are risk factors for epilepsy recurrence in anti-NMDAR encephalitis patients with epileptic seizure.For patients with these factors,longer duration of antiepileptic seizure medicine(ASM)should be used to avoid epilepsy recurrence.
Keywords：Anti-N-methyl-D-aspartate receptor encephalitisEpilepsyRecurrencePrognosisRisk factorsLogistic models
Publication Date：2025-11-25
Online Publishing Date：2025-12-16(First online date of this platform, not the publication date of the document)
Pages：6( 1034-1039 )