Analysis of changes in biomarkers associated with sleep disorders in anti-leucine-rich glioma-inactivated 1 antibody-associated encephalitis
JIANG Shan
LIU Xiao
WANG Sheng-hui
BAI Ying-ying
ZHANG Hong-ju
Abstract：Objective To analyze the changes in biomarkers associated with sleep disorders in anti-leucine-rich glioma-inactivated 1(LGI1)antibody-associated encephalitis,and to preliminarily explore the mechanism of sleep disorders.Methods Fifty patients with anti-LGI1 antibody-associated encephalitis who admitted He'nan Provincial People's Hospital from April 2015 to September 2022 were selected.Serum and cerebrospinal fluid(CSF)samples were collected for biomarkers detection,and Pittsburgh Sleep Quality Index(PSQI)was used to evaluate the presence of sleep disorders.Results The 50 patients were divided into the sleep disorders(>7)group(n=28)and the no sleep disorders(≤7)group(n=22)based on PSQI score.Compared with the no sleep disorders group,the sleep disorders group in serum and CSF showed higher levels of neurofilament light chain(NfL;t=6.690,P=0.000;t=2.356,P=0.023),glial fibrillary acidic protein(GFAP;t=3.713,P=0.000;t=2.768,P=0.008),ionized calcium-binding adapter molecule 1(Iba1;t=5.042,P=0.000;t=3.472,P=0.001),orexin A(t=3.250,P=0.002;t=5.376,P=0.000),cortisol(t=2.487,P=0.016;t=5.779,P=0.000),tumor necrosis factor-α(TNF-α;t=3.832,P=0.000;t=5.122,P=0.000)and chemokine(C-X-C motif)ligand 13(CXCL13;t=2.483,P=0.017;t=4.116,P=0.000),while only interleukin-1β(IL-1β)increased in CSF(t=2.526,P=0.015).Conclusions Sleep disorders associated with anti-LGI1 antibody-associated encephalitis is elevated in levels of neuroinjury markers,neuroendocrine markers and neuroimmune markers,suggesting that sleep disorders associated with anti-LGI1 antibody-associated encephalitis is not a single mechanism and may be related to the extensive involvement of the neuro-endocrine-immune network.
Keywords：EncephalitisAutoimmune diseases of the nervous systemSleep disordersBiomarkers
Publication Date：2025-10-25
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：6( 966-971 )