Combined prediction of mismatch negativity and P300 for the cognitive function in traumatic brain injury patients
DENG Jing
LIU Xia
QIAO Meng-xu
AI Mei-lin
LIU Qi
HUANG Li
Abstract：Objective To investigate the predictive value of mismatch negativity(MMN)combined with P300 for cognitive dysfunction at 6 months after traumatic brain injury(TBI)in adult patients.Methods A total of 75 adult TBI patients admitted to Xiangya Hospital,Central South University from January 2021 to January 2024 were enrolled.MMN and P300 were monitored within 7 d after TBI.Cognitive function was assessed at 6 months after TBI using the Telephone Interview for Cognitive Status(TICS),with a score of<27 indicating cognitive dysfunction.Univariate and multivariate Logistic regression analyses were used to identify influencing factors for cognitive dysfunction at 6 months after TBI.Receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to evaluate the predictive performance of the identified factors.Results Lower absolute value of Fz MMN amplitude(OR=0.426,95%CI:0.188-0.968;P=0.041)and Cz P300 amplitude(OR=0.399,95%CI:0.188-0.847;P=0.017)were identified as risk factors for cognitive dysfunction at 6 months after TBI.ROC curve showed that the AUC for the absolute value of Fz MMN amplitude was 0.713(95%CI:0.595-0.830,P=0.002),with an optimal cutoff value of 2.37 μV.The AUC for the absolute value of Cz P300 amplitude was 0.752(95%CI:0.641-0.863,P=0.000),with an optimal cutoff value of 3.28 μV.When these 2 indicators were combined for ROC curve,the combined indicator yielded an AUC of 0.781(95%CI:0.676-0.886,P=0.000).Delong test revealed no statistically significant differences in AUC between the combined indicator and the absolute value of Fz MMN amplitude(Z=1.574,P=0.115)or the absolute value of Cz P300 amplitude(Z=0.939,P=0.348),suggesting comparable predictive performance among the 3 indicators.Conclusions MMN combined with P300 may serve as a favorable indicator for predicting cognitive dysfunction at 6 months after TBI.
Keywords：Brain injuriestraumaticEvent-related potentialsP300Cognitive dysfunctionRisk factorsLogistic modelsROC curve
Publication Date：2025-10-25
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：8( 910-917 )