Correlation analysis between peripheral blood inflammatory markers and disease severity in acute ischemic stroke patients
TANG Shan-peng
XIONG Bing
Abstract：Objective To investigate the differences in specific peripheral blood inflammatory markers between patients with acute ischemic stroke and healthy controls,exploring the changes in these markers and their clinical significance.Methods A total of 44 patients with acute ischemic stroke from January 2021 to January 2023 in Honghu City People's Hospital,and 29 healthy controls matched to the age and sex were enrolled.Blood inflammatory markers,including peripheral blood white blood cell count,neutrophil count,lymphocyte count,monocyte count,platelet count,platelet to lymphocyte ratio(PLR)and lymphocyte to monocyte ratio(LMR),were analyzed and compared between the 2 groups,and their associations with disease severity[National Institutes of Health Stroke Scale(NIHSS)at admission]were evaluated.Results Compared with healthy controls,the levels of neutrophil(t=2.644,P=0.010)and PLR(t=3.017,P=0.004)were elevated,while levels of lymphocyte(t=3.164,P=0.002)and LMR(t=3.416,P=0.001)were decreased in patients with acute ischemic stroke.Partial correlation analysis showed that peripheral blood PLR in patients with acute ischemic stroke was positively correlated with NIHSS score at admission(r=0.152,P=0.034),while LMR was negatively correlated with NIHSS score at admission(r=-0.154,P=0.033).Conclusions Elevated neutrophil and PLR,alongside decreased lymphocyte and LMR,were observed in acute ischemic stroke patients.These inflammatory markers correlate with disease severity and may aid in the assessment and prediction of disease progression.
Keywords：Ischemic strokeInflammationBiomarkersMonocytesLymphocytesPlatelet count
Publication Date：2025-09-25
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：4( 841-844 )