The impact of early serum phosphorus variability on the early prognosis of patients with moderate-to-severe traumatic brain injury
ZHANG Jie-hua
WANG Ni
ZHU Dong-liang
GAO Jie
WU Chu-wei
HUANG Xian-jian
Abstract：Objective To investigate the predictive value of early serum phosphorus variability on the early prognosis of patients with moderate-to-severe traumatic brain injury(TBI).Methods The retrospective analysis was conducted on the clinical data of 84 patients with moderate-to-severe TBI who admitted to Shenzhen Second People's Hospital from June 2019 to June 2024.The serum phosphorus level within 7 d after admission was determined,and the serum phosphorous variability was calculated.Based on 28 d prognosis after TBI,the patients were divided into the survival group(n=70)and the death group(n=14).Univariate and multivariate Logistic regression analyses were conducted to screen the risk factors of early prognosis in patients with moderate-to-severe TBI.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of the serum phosphorus variability for early prognosis.Results Logistic regression analysis showed that the high serum phosphorus variability was the independent risk factor for 28 d mortality after injury in patients with moderate-to-severe TBI(OR=1.083,95%CI:1.013-1.157;P=0.019).ROC curve showed that the serum phosphorus variability had the significant predictive value for early prognosis,with an area under the curve(AUC)of 0.932(95%CI:0.877-0.986,P=0.000).At a cut-off value of 28.61%,the sensitivity was 100%and the specificity was 75.71%.Conclusions In patients with moderate-to-severe TBI,the early serum phosphorus variability demonstrates a strong predictive value for early mortality,with a higher early serum phosphorus variability associated with poorer early prognosis.
Keywords：Brain injuriestraumaticPhosphorusPrognosisRisk factorsLogistic models
Publication Date：2025-09-25
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：6( 828-833 )