Analysis of prognostic factors in adult glioblastoma
CHENG Hai
XIAO Wei-han
XU Yi-qiang
LI Te
YIN Lu-xin
Abstract：Objective To investigate the related influencing factors that affect the prognosis of adult glioblastoma(GBM)patients.Methods We conducted a retrospective analysis of the molecular pathological data and follow-up information from 96 GBM patients who underwent tumor surgical resection in The Affiliated Hospital of Xuzhou Medical University between January 2019 and April 2022.The presence of TERT promoter mutation,EGFR amplification,and chromosome 7 gain with chromosome 10 deletion(+7/-10)were detected using next-generation sequencing(NGS)technology.The median survival time(MST)of the patients was calculated using Kaplan-Meier survival curve,and univariate and multivariate Cox proportional hazards regression analyses were performed to identify related influencing factors affecting postoperative survival time.Results The Kaplan-Meier survival curve indicated that the MST for GBM patients was 14.50 months.Cox proportional hazards regression analysis revealed that age>60 years old(HR=2.720,95%CI:1.418-5.216;P=0.003),preoperative Karnofsky Performance Status(KPS)score<80(HR=2.481,95%CI:1.455-4.232;P=0.001),TERT promoter mutation(HR=2.846,95%CI:1.455-5.569;P=0.002),EGFR amplification(HR=3.263,95%CI:1.770-6.015;P=0.000),and the presence of+7/-10(HR=2.349,95%CI:1.272-4.337;P=0.006)were identified as risk factors associated with shortened postoperative survival time.In contrast,gross total resection of the tumor(HR=0.246,95%CI:0.132-0.458;P=0.000)and postoperative combined chemoradiotherapy(HR=0.368,95%CI:0.212-0.639;P=0.000)were protective factors associated with prolonged postoperative survival time.Conclusions GBM patients exhibiting TERT promoter mutation,EGFR amplification and+7/-10 have a poorer prognosis.Routine clinical testing of TERT promoter status,EGFR amplification,and chromosomal copy number variations(+7/-10)are beneficial for accurately assessing patient prognosis.
Keywords：GlioblastomaTelomeraseErbB receptorsBiomarkerstumorPathologymolecularKaplan-Meiers estimateAdult
Publication Date：2025-08-25
Online Publishing Date：2025-09-22(First online date of this platform, not the publication date of the document)
Pages：7( 771-777 )