Analysis of influencing factors of acute kidney injury after spontaneous intracerebral hemorrhage surgery
ZHANG Lei
QU Tong-jun
WU Sheng
ZHANG Tao
ZHANG Guo-bin
Abstract：Objective To analyze the influencing factors of acute kidney injury(AKI)after surgery in spontaneous intracranial hemorrhage(sICH).Methods A total of 151 patients with sICH who underwent surgery in Tianjin Huanhu Hospital from March 2023 to June 2024 were selected.According to whether AKI occurred after surgery,they were divided into AKI group(n=100)and non-AKI group(n=51).Logistic regression analyses were used to screen the influencing factors of AKI after surgery in patients with sICH.The receiver operating characteristic(ROC)curve was drawn to evaluate the predictive efficacy of intracranial pressure(ICP)and serum neuron-specific enolase(NSE)3 d after surgery and their combination for AKI.Results Logistic regression analysis showed that increased cardiac troponin(OR=1.011,95%CI:1.005-1.017;P=0.001),and increased ICP 3 d after surgery(OR=1.289,95%CI:1.126-1.477;P=0.000)were the risk factors for AKI after surgery in sICH patients.ROC curve showed that the area under the curve(AUC)of ICP and serum NSE 3 d after surgery and their combination in the prediction of AKI after surgery were 0.729(95%CI:0.649-0.810,P=0.000),0.720(95%CI:0.631-0.809,P=0.000)and 0.751(95%CI:0.672-0.830,P=0.000),the sensitivity were 45%,73%and 51%,and the specificity were 88.24%,66.67%and 90.20%.There was no significant difference in the AUC among the 3 indicators(P>0.05,for all).Conclusions The increased cardiac troponin and ICP 3 d after surgery were risk factors for AKI after surgery in sICH.Moreover,the elevated ICP and serum NSE 3 d after surgery can predict the occurrence of AKI,but the combined monitoring does not improve the prediction efficiency.
Keywords：Cerebral hemorrhageAcute kidney injuryIntracranial pressurePhosphopyruvate hydrataseRisk factorsLogistic modelsROC curve
Publication Date：2025-07-25
Online Publishing Date：2025-08-28(First online date of this platform, not the publication date of the document)
Pages：11( 650-660 )