Role of melatonin in pathological injury mechanism of Alzheimer s disease
JIANG Jia-feng
ZHAO Lian-hua
ZHAO Wei
Abstract：Melatonin is an important hormone regulating sleep and wake cycle,which can alleviate and delay the progression of Alzheimer's disease(AD)by reducing amyloid-β protein(Aβ)deposition,inhibiting tau protein hyperphosphorylation,alleviating oxidative stress damage and inflammatory response,improving cholinergic system function,regulating neuronal autophagy,and other mechanisms.This article reviews the role of melatonin in the pathological injury mechanism of AD,so as to explore the clinical application prospect of melatonin in AD.
Keywords：Alzheimer diseaseMelatoninReview
Publication Date：2023-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 687-692 )