Progress on biomarkers of idiopathic rapid eye movement sleep behavior disorder conversion to neurodegenerative diseases
ZHANG Xuan
XUE Rong
Abstract：Idiopathic rapid eye movement sleep behavior disorde(iRBD)is a precursor symptom of neurodegenerative diseases,and most patients will convert to neurodegenerative diseases later in the disease.Reliable biological markers are of great significance for early identification of high-risk converters and predicting phenoconversion pattern.This paper reviews the research progress of biological markers in predicting conversion to neurodegenerative diseases in iRBD from clinical symptomology,neuroelectrophysiology,neuroimaging,body fluid,pathology and gene markers,in order to select patients suitable for disease modification therapy and delay the development of neurodegenerative diseases.
Keywords：REM sleep behavior disorderNeurodegenerative diseaseBiomarkersReview
Publication Date：2023-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 668-673 )