Risk factors of in-stent restenosis for intracranial artery stenosis: a Meta-analysis
LI Qian
XU Da
CHEN Deng
ZHU Li-na
WANG Hai-jiao
TAN Ge
ZHANG Yu
LIU Ling
Abstract：Objective To assess the risk factors of in-stent restenosis (ISR) for intracranial artery stenosis by Meta-analysis.Methods Retrieve relevant case-control studies or cohort studies from online databases (January 1,1990-August 1,2017) as PubMed,EBMASE/SCOPUS and Cochrane Library with key words:intracranial artery,stent,restenosis,risk factors,predictors.Selection of studies was performed according to pre-designed inclusion and exclusion criteria.Quality of studies was evaluated by using Newcastle-Ottawa Scale (NOS).All data were pooled by RevMan 5.3 software for Meta-analysis.Results The research enrolled 305 articles,from which 16 high-quality (NOS score ≥ 6) studies were chosen after excluding duplicates and those not meeting the inclusion criteria.A total of 1102 cases (ISR:N =245;nonISR:N =857) were included.Meta-analysis showed that diabetes (OR =1.880,95％CI:1.290-2.740;P =0.001),lesions stenosis length ＞ 10 mm (OR =3.550,95％CI:1.160-10.850;P =0.030),anterior circulation lesions (OR =1.680,95％CI:1.170-2.420;P =0.005),postoperative residual stenosis ≥ 30％ (OR =3.290,95％CI:1.460-7.410;P=0.004) and bare metal stents (OR =4.290,95％CI:1.130-16.260;P=0.030)increased the risk of ISR significantly.Conclusions Diabetes,lesions stenosis length ＞ 10 mm,anterior circulation lesions,postoperative residual stenosis ≥ 30％ and bare metal stents were risk factors of in-stent restenosis.Clinicians should avoid related risk factors and reduce the occurrence of in-stent restenosis.
Keywords：Intracranial arteriosclerosisStentsRisk factorsMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 183-191 )