Investigation of pathogenetic mechanism, prevention and treatment of Alzheimer's disease via systemic approaches
WANG Yan-jiang
BU Xian-le
XIANG Yang
LIU Yu-hui
JIAO Shu-sheng
WANG Qing-hua
ZENG Fan
JIN Wang-sheng
WANG Jun
LI Ling
CHEN Yang
ZHANG Tao
ZHU Jie
DENG Juan
YAO Xiu-qing
GAO Chang-yue
ZHANG Li-li
ZHANG Meng
XU Zhi-qiang
ZHOU Hua-dong
Abstract：Alzheimer's disease (AD) becomes a major disease affecting the elderly with high prevalence.However,no disease-modifying therapies are currently available.AD has long been regarded as a disease of brain itself,but recent studies found that systemic disorders are associated with risk for AD.During the period of Twelfth Five-Year Plan for National Economic and Social Development,our team tried to reveal the pathogenesis,targets,amyloid β-protein (Aβ) clearence pathway and drugs from both central and peripheral approaches,and have discovered:1) the ratio of p75 neurotrophin receptor (p75NTR) in the brain of AD regulates the over-production and clearence of Aβ in sporadic AD.2) Peripheral Aβ is able to enter brain,forms AD-type pathologies and induces neuronal deficits,revealing the peripheral mechanism of AD.3) The effectiveness and safety of brain A β clearance by peripheral organs and tissues has been verified.Based on these findings,we proposed a systemic view of AD,to understand pathogenesis and develop novel diagnostic methods and therapies from a systemic approach.
Keywords：Alzheimer diseaseAmyloid beta-proteinChinaReview
Publication Date：2018-01-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 25-29 )