The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease
WU Hao
LI Xu-dong
PENG Dan-tao
JIAO Jin-song
LI Yan-feng
YU Pu-lin
JI Yong
Abstract：Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis.The typical pathological changes of AD include neuritic plaques [NPs,senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) due to abnormal aggregation of tau protein.Researches show that cholinergic system is related to AD,and butyrylcholinesterase (BChE) plays an important role in AD.This article reviews the important role of BChE in the pathogenesis of AD.
Keywords：Alzheimer diseaseButyrylcholinesteraseReview
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 933-936 )