MRI combined with 18F-FDG PET and 11C-MET PET in differentiating tumefactive demyelinating lesion and glioma
YANG Yi-han
CAI Li
MA Hai-wen
WANG Ying
BAI Yu
MING Hao-lang
YU Sheng-ping
REN Bing-cheng
LIN Yu
ZHANG Kai
HAI Long
WANG Wei
CHENG Cheng
LI Tao
YANG Xue-jun
Abstract：Objective To explore the value of MRI combined with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) PET and 11C-methionine (11C-MET) PET on differentiating tumefactive demyelinating lesion (TDL) and glioma.Methods Fourteen cases of TDL and 17 cases of glioma were confirmed by pathology directly or internal medicine treatment.MRI was used to observe the lesion boundary,T1WI,T2WI and diffusion weighted imaging (DWI) signal intensity,enhancement (including ring enhancement and open-ring enhancement,etc.),mass effect,peripheral edema,and the presence of central venectasia,corpus callosum engagement,central necrosis and gray matter engagement.18F-FDG PET and 11C-MET PET were used to calculate relative uptake values.Results Among all TDL cases,MRI showed that mass effect of 8 cases (8/14) were grade 0,4 cases (4/14) grade Ⅰ,one case (1/14) was grade Ⅱ and one case (1/14) gradeⅢ;the peripheral edema of 12 cases (12/14) were grade Ⅰ and 2 cases (2/14) grade Ⅱ.Among all glioma cases,the mass effect of 2 cases (2/17) were grade 0,6 cases (6/17) grade Ⅰ,7 cases (7/17) grade Ⅱ and 2 cases (2/17) grade m;the peripheral edema of 7 cases (7/17) were grade Ⅰ and 10 cases (10/17) grade Ⅱ.The differences between TDL and glioma were statistically significant (Fisher's exact probability:P =0.032,0.024).18F-FDG PET and 11C-MET PET were not statistically significant in differentiating TDL and glioma (Fisher's exact probability:P =0.182,0.081).Conclusions Mass effect and peripheral edema showed in MRI can be used for the differential diagnosis of TDL and glioma.The value of PET-CT in differentiating TDL and glioma is unsure.
Keywords：Demyelinating diseasesCentral nervous systemGliomaMegnetic resonance imagingTomographyemission-computed
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 754-761 )