Research progress of narcolepsy
XIAO Fu-long
ZHANG Jun
HAN Fang
Abstract：The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine.Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal.Basic research about Hcrt/Orexin system has been applied in clinical practice and the measurement of Hcrt/Orexin in the cerebrospinal fluid (CSF) is the golden criteria and classification basis for diagnosis of narcolepsy.Breakthrough advance has been made in genetic immunology of hypothalamus Hcrt/Orexin neuronal apoptosis of narcolepsy patients.Medications aimed at Hcrt/Orexin receptors are considered to be a novel target in the treatment of sleep disorders.
Keywords：NarcolepsyReview
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 644-647 )