Research progress of neuroimaging of blood-brain barrier breakdown in Alzheimer's disease patients
XU Qin
BAI Feng
Abstract：Recent studies indicate that blood-brain barrier (BBB) breakdown may play an important role in the pathophysiology of cognitive dysfunction and dementia.BBB regulates the homeostasis of brain microenvironment,controls the transfer of required nutrients (e.g.,glucose and amino acids),and limits entry of blood-derived products,pathogens and neurotoxins into the brain tissue.Recent advances in neuroimaging techniques offer new possibilities to realize positioning and quantitative detection of BBB disruption.It provides a new insertion point for elucidating the pathogenesis of Alzheimer's disease (AD).
Keywords：Alzheimer diseaseBlood-brain barrierMagnetic resonance imagingReview
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 462-466 )