DOI: 10.12307/2026.309
Occurrence and development of plant derived extracellular vesicles in the prevention and treatment of musculoskeletal system diseases
Zhang Yijie
Hong Bowen
Zhou Yi
Shao Yang
Wu Mao
Li Shaoshuo
Wang Jianwei
Abstract：BACKGROUND:Plant derived extracellular vesicles have opened up new avenues for the treatment of osteoporosis,osteoarthritis,and cartilage damage due to their unique biological properties and low immunogenicity.
OBJECTIVE:To review the research history,extraction and separation methods of plant derived extracellular vesicles,and their application progress in musculoskeletal system diseases.
METHODS:Relevant literature published from January 1995 to February 2025 was searched by computer in PubMed,Web of Science,EMbase,China National Knowledge Infrastructure(CNKI),WanFang,and VIP databases using"musculoskeletal system,plant derived extracellular vesicles,exosomes,extracellular vesicle like nanovesicles,osteoporosis,osteoarthritis,wound healing,drug carrier,inflammation"as Chinese and English search terms.Finally,61 articles were included for analysis.
RESULTS AND CONCLUSION:The advantages of plant derived extracellular vesicles include relatively simple extraction and purification processes,easy standardization,suitability for large-scale production,lower immunogenicity,greater safety and tolerance,excellent stability,ability to withstand acidic conditions in the stomach and intestines,suitability for oral administration systems,longer in vivo circulation time and tissue-specific targeting,and the ability to cross the blood-brain barrier but not the placental barrier.Plant derived extracellular vesicles have been widely studied in the treatment of osteoporosis,osteoarthritis,promotion of wound healing and blood flow reconstruction,inhibition of inflammatory reactions,and as drug carriers for the treatment of musculoskeletal system diseases.
Keywords：plant derived extracellular vesiclemusculoskeletal systemosteoporosisosteoarthritiswound healingdrug carrierinflammation
Publication Date：2026-05-08
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：9( 3370-3378 )