Mechanism of programmed cell death mediated by total flavonoids of Rhizoma Drynariae

Han Yapeng; Gao Jun; Niu Yunwei; Deng Enjia

doi:10.12307/2026.723

Abstract：BACKGROUND:The programmed death of bone-related cells is closely related to common clinical bone-associated diseases such as osteoporosis and osteoarthritis,and the total flavonoids of Rhizoma Drynariae has been identified to be used to regulate the programmed death of bone-related cells and is characterized by multi-target regulation and low toxicity. OBJECTIVE:To review the research progress on the mechanism by which the total flavonoids of Rhizoma Drynariae regulates bone-related cell programmed death. METHODS:Relevant articles were searched by the first author in CNKI,VIP,PubMed,and Web of Science databases,and the search terms used were"total flavonoids of Rhizoma Drynariae,naringin,naringenin,luteolin,kaempferol,programmed death,bone,cell"in both English and Chinese.According to inclusion and exclusion criteria,72 papers were finally included for review. RESULTS AND CONCLUSION:By affecting various signaling pathways and molecular expressions such as phosphatidylinositol 3-kinase/protein kinase B,Wnt/β-catenin,and silent information regulator 3/forkhead box protein O3a,total flavonoids of Rhizoma Drynariae can reduce the mortality of mesenchymal stem cells,osteoblasts and chondrocytes,increase the mortality of osteoclasts,and correct bone homeostasis imbalance and cartilage degeneration,which provides a new perspective for the treatment of bone-related diseases.In the future,we can integrate different omics and sequencing technologies to systematically analyze the molecular network through which the total flavonoids of Rhizoma Drynariae regulate programmed cell death of bone-related cells,and explore the multi-target and multi-pathway therapeutic mechanisms of total flavonoids of Rhizoma Drynariae,providing new ideas and methods for the treatment of bone-related diseases.