The relationship between gout and some lifestyles,cardiovascular disease,bone disease,and psychiatric disease

Liu Shuhong; Xie Yuhan; Huang Chengcheng; Yang Zhenguo; Li Yang

doi:10.12307/2026.618

Abstract：BACKGROUND:The onset of gout is directly associated with disorders of purine metabolism and/or reduced uric acid excretion.Currently,the etiological factors of gout and its relationship with other diseases are not fully understood.Mendelian randomization studies can effectively mitigate confounding factors and reverse causality,thereby providing novel perspectives and approaches for investigating the associations between gout and various risk factors/diseases. OBJECTIVE:To summarize currently published Mendelian randomization studies related to gout,focusing on the causal relationship between lifestyles,various diseases and metabolites and the development of gout. METHODS:A computerized search was conducted to identify relevant literature published in CNKI and PubMed databases from 2014 to 2024.The search terms were"gout,Mendelian randomization,causality,lifestyle,drinking,alcohol,tea,coffee,mental illness,Alzheimer's disease,cardiovascular disease,bone disease,osteoarthritis,hypertension,angina,obesity"in Chinese and English,respectively.A total of 88 papers were finally included for review. RESULTS AND CONCLUSION:Current Mendelian randomization studies predominantly support causal relationships between gout and various factors including lifestyles(e.g.,tea/coffee consumption),metabolic products,endocrine disorders,obesity,cardiovascular diseases,gut microbiota,micronutrients,novel COVID-19 infection,skeletal disorders,and psychiatric diseases.However,some Mendelian randomization findings do not confirm a causal relationship between gout and some lifestyle conditions(e.g.,alcohol consumption),cardiovascular diseases,skeletal disorders,or psychiatric diseases.Although there are some limitations and deficiencies in Mendelian randomization studies,the current conclusions still help us to have a more comprehensive understanding of the pathogenesis of gout and its relationship with other diseases.