Immune inflammatory microenvironment mechanisms in peri-implantitis

Chen Haojie; Wang Dai; Shen Shan

doi:10.12307/2026.563

Abstract：BACKGROUND:The development of peri-implantitis is closely related to its immuno-inflammatory microenvironment,and the treatment of peri-implantitis by clarifying the mechanism of the immuno-inflammatory microenvironment is an important direction of research at present. OBJECTIVE:To review the mechanism and research progress of the immuno-inflammatory microenvironment in peri-implantitis. METHODS:"Peri-implantitis,bone integration,immune inflammatory microenvironment,microbiological profile,immune response mechanism,signaling pathway"were used as Chinese and English search terms.Literature searches were conducted in PubMed and CNKI,and the time limit for searching was from the time of database construction to September 2024.Literature obtained from the screening search was analyzed,summarized and concluded,and finally 79 relevant papers were summarized. RESULTS AND CONCLUSION:(1)The occurrence and development of peri-implantitis is closely related to its complex microbial characteristics,which stimulates the body to produce an immune-inflammatory response and exacerbates peri-implant bone resorption,and the signaling pathway plays an important role in regulating the process.Due to the limitations of the current development of technologies such as microbial cultivation and proteomics,the understanding of microbial characteristics,immune response mechanisms,and signaling pathways in peri-implantitis is still not comprehensive enough.Therefore,a lot of clinical and basic research is still needed for peri-implantitis.(2)According to the characteristics of the immuno-inflammatory microenvironment of peri-implantitis,reducing the release of pro-inflammatory factors,modulating the relevant signaling pathways,inhibiting alveolar bone resorption,and promoting new bone generation is expected to be an effective strategy for the prevention and treatment of peri-implantitis.