Applications and limitations of antioxidant nanomaterials in oral cavity

Yang Xuetao; Zhu Menghan; Zhang Chenxi; Sun Yimin; Ye Ling

doi:10.12307/2026.026

Abstract：BACKGROUND:Oxidative stress is linked to the development of numerous oral disorders.Antioxidant nanomaterials possess enhanced reactive oxygen species scavenging properties and can reduce oxidative stress,presenting significant potential for application in oral health. OBJECTIVE:To summarize the research progress of antioxidant nanomaterials in recent years,as well as their applications,deficiencies,and future research directions in oral diseases. METHODS:Literature was retrieved in PubMed and Web of Science databases using the keywords"reactive oxygen,antioxidant,nano,oxidative stress,oral,"and literature was retrieved in CNKI using the same keywords.Articles with weak relevance to the research topic were excluded,resulting in a final inclusion of 103 publications for analysis. RESULTS AND CONCLUSION:Oxidative stress is one of the mechanisms underlying the pathogenesis of various oral diseases.Eliminating excess reactive oxygen species and rebalancing oxidation and antioxidation is a crucial approach to treating oral-related diseases.Antioxidant nanomaterials have efficient reactive oxygen species scavenging ability due to their nanostructure characteristics,can improve the body's oxidative stress,promote the recovery of related diseases,and have significant effects in the research and application of oral-related diseases.The raw materials for the synthesis of antioxidant nanomaterials are expensive,the process is complex,and the long-term safety of in vivo application is unclear,which requires further research,improvement and verification.In the future,the research and application of antioxidant nanomaterials in oral diseases require multidisciplinary cross-disciplinary research,while combining fields such as big data and artificial intelligence to optimize the design,experiment,application,and verification of materials to achieve safe,effective,and comfortable personalized oral disease treatment.