DOI: 10.12307/2026.073
Bidirectional regulation of reactive oxygen species based on zeolitic imidazolate framework-8 nanomaterials:from tumor therapy and antibacterial activity to cytoprotection
Wang Songpeng
Liu Yusan
Yu Huanying
Gao Xiaoli
Xu Yingjiang
Zhang Xiaoming
Liu Min
Abstract：BACKGROUND:Zeolitic imidazolate framework-8 and its derivatives have demonstrated significant potential in tissue engineering due to their excellent drug-controlled release capabilities.
OBJECTIVE:To review the mechanisms of reactive oxygen species generation and clearance by zeolitic imidazolate framework-8 and its modified materials,explore their potential applications in antitumor,antibacterial,and tissue protection fields,and analyze future directions and challenges.
METHODS:The first author conducted a literature search in CNKI and PubMed databases for publications from 2000 to 2024.The Chinese keywords included"zeolitic imidazolate framework-8,reactive oxygen species,antibacterial,anti-tumor,reactive oxygen species absorption,reactive oxygen species balance,tissue repair."English keywords included"ZIF-8,ROS,antibacterial,antitumor,ROS absorption,balance of ROS,tissue regeneration."A total of 69 high-quality articles were selected for review and analysis.
RESULTS AND CONCLUSION:By modulating the band gap structure of zeolitic imidazolate framework-8 and its modified materials and optimizing electron transfer efficiency,the separation and migration efficiency of photoinduced charge carriers can be significantly enhanced.This improvement boosts catalytic reaction performance,increases generation efficiency of reactive oxygen species,and achieves more effective and targeted antitumor and antibacterial effects.Simultaneously,antioxidant enzyme systems or surface-modified reactive oxygen species scavenging devices can precisely balance excessive reactive oxygen species,providing effective cell protection.This dual regulation mechanism,based on band gap tuning and electron transfer optimization,offers a strategic approach to dynamically manage reactive oxygen species generation and clearance,presenting broad application prospects in antitumor,antibacterial,and tissue protection fields.
Keywords：zeolitic imidazolate framework-8reactive oxygen speciesreactive oxygen species regulationantitumorantibacterialtissue engineering
Publication Date：2026-03-18
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：11( 2033-2043 )