Advantages of MXene-based flexible electronic sensors and their application in monitoring diabetic foot wounds

Pan Zhiyi; Huang Jiawen; Xue Wenjun; Xu Jianda

doi:10.12307/2026.056

Abstract：BACKGROUND:MXene materials have excellent antibacterial activity,electrical conductivity,photothermal conversion activity,and biocompatibility,which can be engineered as flexible electronic sensors and have great application potential in the field of real-time monitoring of diabetic foot wounds. OBJECTIVE:To review the advantages of MXene-based flexible electronic sensors and their current utilization and future perspectives in the monitoring of diabetic foot wound. METHODS:PubMed,Web of Science,CNKI,and WanFang databases were searched with Chinese and English search terms"MXene,flexible electronic sensor,diabetic foot,wound detection."A total of 55 articles were included for review analysis. RESULTS AND CONCLUSION:The physiological parameters,such as pH value,temperature,uric acid,blood glucose,superoxide anion,and hydrogen peroxide,are considered closely related with diabetic wound healing.MXene-based flexible electronic sensors exhibit better real time monitoring capability and have broad development prospects.According to the inherent characteristics of MXene materials,creative surface modification of traditional flexible sensors can not only give the sensors good antibacterial ability,but also improve the overall performance of the sensors,and show higher redox current response by enhancing the sensitivity to changes in pathological signals,thus achieving accurate and stable dynamic monitoring.Although MXene-based flexible electronic sensors have made great progress in monitoring diabetic foot wounds,most of the current research is still in infancy,and long-term biosafety and system validation need to be further studied.