Local application of osteoporosis treatment drugs in oral field

Ma Ling; Zhang Zhao

doi:10.12307/2025.952

Abstract：BACKGROUND:With the population aging,the incidence of osteoporosis is on the rise.Currently,common anti-osteoporosis drugs include bisphosphonates,receptor activator of nuclear factor-κB ligand(RANKL)inhibitors(denosumab),statins,and parathyroid hormone.These drugs can effectively inhibit osteoclast synthesis and activity through different signaling pathways,thereby inhibiting bone resorption and increasing bone density. OBJECTIVE:To analyze and summarize the research progress on the local application of several common anti-osteoporosis drugs in the oral field. METHODS:Relevant literature was retrieved from China National Knowledge Infrastructure and PubMed databases.The Chinese and English search terms were"bisphosphonates,anti-RANKL antibodies,statins,parathyroid hormone,traditional Chinese medicine,implant,periodontitis,orthodontic tooth movement,alveolar bone resorption,replanted teeth,local application."Finally,79 articles were included for summarization. RESULTS AND CONCLUSION:(1)Local application of osteoporosis treatment drugs on the implant surface,or the use of carriers to deliver drugs locally to the implant site can enhance the osseointegration of the implant and improve the stability of the implant.(2)Topical application of osteoporosis drugs as an adjunct to conventional periodontal therapy can lead to significant clinical and radiographic improvements,and is equally effective for smokers and well-controlled diabetic patients.Different types of drugs have differences in efficacy.(3)Local application of osteoporosis treatment drugs may be beneficial in regulating orthodontic tooth movement,reducing orthodontic anchorage loss and post-orthodontic recurrence.(4)Local application of bisphosphonates and statins can promote bone formation and preserve the alveolar ridge after tooth extraction,and reduce alveolar bone absorption.(5)Root surface treatment with bisphosphonates and denosumab has a certain effect on preventing ankylosing of delayed replanted teeth and reducing replacement resorption.