DOI: 10.12307/2025.521
Action mechanism and progress of stem cells against ovarian granulosa cell senescence
Lin Meiyu
Zhao Xilong
Gao Jing
Zhao Jing
Ruan Guangping
Abstract：BACKGROUND:As an emerging treatment method,stem cell therapy is expected to improve the ovarian environment,delays the aging of ovarian granulosa cells,and brings new hope to older pregnant women.
OBJECTIVE:To review the mechanism and research progress of stem cells against ovarian granulosa cell senescence.
METHODS:CNKI and PubMed databases were retrieved for articles on stem cell therapy for ovarian granulosa cell senescence.Chinese and English search terms were"stem cells,ovary granulosa cells,aging."Finally,67 articles were included for analysis.
RESULTS AND CONCLUSION:(1)This review summarizes five mechanisms of ovarian granulosa cell senescence:DNA damage and decreased repair capacity,oxidative stress,impaired mitochondrial function,inflammatory response,and changes in hormone levels.(2)This article summarizes five main mechanisms of stem cells in the treatment of ovarian granulosa cell senescence:promoting proliferation and inhibiting apoptosis,differentiation potential and regeneration ability,secreting factors,anti-oxidation,anti-inflammatory response,and immune regulation.(3)At present,there are various types of stem cells that can cooperate to treat ovarian granulosa cell senescence through a variety of ways,and stem cell therapy has broad prospects in restoring female fertility.
Keywords：stem cellovarian granulosa cellagingmechanismoxidative stressinhibition of apoptosiscytokineantioxidantanti-inflammatory response
Publication Date：2025-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 5414-5421 )