Prostaglandin E2 in repair of skeletal muscle injury

Li Xinlei

doi:10.12307/2025.901

Abstract：BACKGROUND:Prostaglandin E2 is a lipid signaling molecule involved in pain and inflammatory responses,can enhance tissue repair and regeneration after injury in various organ systems and directly targets muscle satellite cells through the EP receptor family,promoting their proliferation,differentiation,and migration. OBJECTIVE:To summarize the process,mechanisms,and practical applications of prostaglandin E2 in promoting skeletal muscle repair and regeneration. METHODS:A search was conducted in Web of Science,PubMed,and China National Knowledge Infrastructure(CNKI)for relevant literature from the inception of the databases up to the present.The English search terms included"Muscle,Skeletal,Skeletal Muscle*,Voluntary Muscle*,Dinoprostone,PGE2*,Prostaglandin E2,Injur*,repair,"while the Chinese search terms were"Skeletal Muscle,Injury,Repair,Prostaglandin E2,PGE2."A total of 50 articles were included and analyzed. RESULTS AND CONCLUSION:Prostaglandin E2 is of great significance for the timely and effective repair and regeneration of skeletal muscle,as well as the restoration of its function.It can regulate the proliferation and self-renewal of muscle stem cells through the CREB-MPP7-AMOT pathway,accelerate the G1-S transition during the interphase of cell division,and regulate reactive oxygen species to promote the proliferation of primary myoblasts.Furthermore,exogenous means of inhibiting prostaglandin E2 degradation can promote muscle regeneration,and sustained-release methods can extend the half-life of prostaglandin E2.