DOI: 10.12307/2025.466
Effects of self-assembling peptide hydrogels on tumor treatment
He Huanhuan
Tian Shijia
Chen Luoying
Liu Yanfei
Abstract：BACKGROUND:Self-assembling peptide hydrogels exhibit excellent biocompatibility,controllable physicochemical properties,and release capabilities,offering extensive application potential in tissue engineering,drug delivery,and biosensing fields.
OBJECTIVE:To summarize the research progress of self-assembling peptide hydrogel in cancer therapy in recent years.
METHODS:Using the search terms"self-assembling peptides,hydrogel,sustained release,antitumor,tumor therapy"in Chinese and English,CNKI,PubMed,and Elsevier ScienceDirect databases were searched for relevant literature published from 2000 to 2024.Finally,81 articles were included in the review.
RESULTS AND CONCLUSION:Self-assembling peptide hydrogels,as a novel biomaterial,can be used as a sustained-release drug carrier to load a variety of anti-tumor drugs,and immunosuppressants,targeting tumor sites,inducing tumor cell death,reducing drug dosage,and increasing drug accumulation in tumor sites,thereby reducing the probability of toxic side effects and multidrug resistance.Moreover,anti-tumor hydrogels with natural activity can directly kill tumor cells without relying on drugs,and can minimize the toxic side effects of anti-tumor drugs when used alone.
Keywords：self-assembling peptidehydrogelsustained releaseanti-tumortissue engineering
Publication Date：2025-08-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 4795-4803 )