Preparation and evaIuation of bacteriaI nano-ceIIuIose/chitosan composite tubes as potentiaI smaII-diameter vascuIar grafts
Li Xue
Tang Jing-yu
Bao Lu-han
Chen Lin
Hong Feng
Abstract：BACKGROUND: There are still no applicable vascular grafts for clinical replacement of the small-diameter blood vessels (< 6 mm). OBJECTIVE: To explore the possibility of bacterial nano-cellulose (BNC)/chitosan (CH) composite tubes as small-diameter artificial blood vessels. METHODS: BNC/CH tubes were fabricated by introducing chitosan (0.5%, 1%, 2%) into BNC tubes. Physicochemical properties of BNC/CH tubes were analyzed including macro-morphology, microstructure, density, water-holding capacity, burst pressure, mechanical properties, blood compatibility and cytocompatibility. RESULTS AND CONCLUSION: The results indicated that, as compared with the BNC tubes, the water permeability of BNC/CH tubes reduced, the density and water-holding capacity increased, as well as the axial and radial mechanical performance was enhanced, but ductility and elasticity of BNC/CH tubes were weakened. Regarding blood compatibility, hemolysis ratios of BNC and BNC/CH met the requirements of medical grade composites, while the plasma recalcification time showed that anticoagulation of BNC/CH tubes was slightly weaker than that of the BNC tubes. Cell compatibility experiments showed that porcine hip artery endothelial cells stably proliferated on the inner surface of both BNC and BNC/CH tubes, but the proliferation was more obvious on the BNC surface than on the BNC/CH surface.
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Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 5467-5473 )