Establishment and assessment of small animal models of osteoarthritis

Wu Wei; Li Hui; Zou Jun; Wang Miao

doi:10.3969/j.issn.2095-4344.2017.28.017

Abstract：BACKGROUND:Animal models of osteoarthritis are of great significance for the studies on its pathogenesis,prevention and treatment.There are various osteoarthritis models that certainly simulate the development of human osteoarthritis.Some stimulating factors have been found to participate in the occurrence and development of osteoarthritis.OBJECTIVE:To review the recent researches about animal models of osteoarthritis at home and abroad,and to assess different modeling methods and some stimulating factors related to the occurrence and development of osteoarthritis.METHODS:A computer-based retrieval of CNKI and PubMed databases before December 2016 was performed with the keywords of "osteoarthritis,animal models,stimulating factors,assessment grading system,outcome measurement" in Chinese and English,respectively.Finally 57 eligible papers were included for analysis.RESULTS AND CONCLUSION:(1) In recent years,the osteoarthritis models are mainly established by doing damage to the cruciate ligaments and meniscus,and evaluated by Mankin score;the age of experimental animals tend to be younger.(2) Animals developed maturely are rational,so as to avoid the effect of self-healing caused by growth factors on osteoarthritis occurrence.