Effect of constipation induced by diphenoxylate on intestinal flora in a rat
Li Gen-lin
Zhang Yan-yu
Li Han-bing
Abstract：BACKGROUND:In the previous studies, the overal index in constipation models, such as fecal output in 24 hours and intestinal tension are usual y measured. However, the changes of intestinal flora are rarely involved. <br> OBJECTIVE:To explore the effect of constipation on intestinal tension, pathology and microecology in the rat models of diphenoxylate-induced constipation. <br> METHODS:Twenty SPF Wistar rats were randomly divided into blank control and model groups, followed by given 10 mg/kg diphenoxylate and distilled water by gavage once daily for 20 days, respectively. <br> RESULTS AND CONCLUSION:Twenty days later, compared with the blank control group, the frequency of ileum contraction was decreased, 24-hour stool decreased, the ratio of bacteria group in the cecum changed, and structure of the colon was seriously damaged in the model group. These results suggest that constipation results in the intestinal flora disturbance remarkablely.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 7404-7410 )