Molecular mechanism of magnesium ions in bone metabolism:research and progress
Shang Xiao-pan
Li Tao
Lu Yu-tong
Deng Wei
Wang Wen-ju
Yang Yong-jin
Abstract：BACKGROUND:The magnesium ions released from the degradation of magnesium al oy are an important cation in human body, which not only participate in various metabolic activities, but also regulate bone <br> metabolism and involved in the reconstruction and stability of bone. Therefore, the abnormal concentration of magnesium ions can lead to bone metabolism related diseases. <br> OBJECTIVE:To review the function and mechanisms of magnesium ions in bone metabolism and overview the related cytokines and signaling pathways. <br> METHODS:A computer-based research of CJFD, PubMed and WanFang databases was performed for pertinent articls published from January 2000 to February 2016 using the keywords of“magnesium, bone metabolism, PI3K/Akt signal pathway, OPG/RANKL signal pathway, TRPM, and Wnt signal pathway”in Chinese and English, respectively. <br> RESULTS AND CONCLUSION:The magnesium ions released from the degradation of magnesium al oy expose influence on the bone metabolism by regulating the related signaling pathways. The concentration changes of magnesium ions can induce the changes in cytokines in the signaling pathways related to bone metabolism, and further act on the bone remodeling. Whether the magnesium ions participate in bone metabolism through other pathways wil be a hot spot.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 7280-7287 )