Biocompatibility of different hemodialysis membrane materials in the treatment of severe acute pancreatitis

Jiang Qi-dong; Wu Chang-xue

doi:10.3969/j.issn.2095-4344.2016.47.016

Abstract：BACKGROUND:In the clinical treatment of severe acute pancreatitis, there are different dialysis membrane materials. But the differences among these dialysis membrane materials are unclear. OBJECTIVE:To compare the biocompatibility of polysulfone and cel ulose acetate dialysis membranes. METHODS:Total y 100 severe acute pancreatitis patients were included, including 51 males and 49 females, aged 34 to 81 years, and al were subjected to hemodialysis treatment (5 hours once, three times per week). Polysulfone membrane was used in 50 cases, and cel ulose acetate dialysis membrane used in the other 50 cases. After 3 months of fol ow-up, the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, therapeutic efficacy and level of inflammatory factors were compared between two groups. RESULTS AND CONCLUSION:There were no differences in the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, and therapeutic efficacy between the two groups. The levels of interleukin-6, C-reactive protein and tumor necrosis factor alpha in the two groups were significantly lower than those before hemodialysis treatment (P<0.05), but there was no significant difference between the two groups. Results show that both polysulfone and cel ulose acetate membranes used in hemodialysis treatment of severe acute pancreatitis have good biocompatibility.