Effect of polytetrafluoroethylene artificial blood vessels on platelet aggregation and its cytocompatibility
Jiang Zheng-ming
Chen Kui
Hu Cai-na
Abstract：BACKGROUND:Polytetrafluoroethylene artificial blood vessels have been extensively used in clinic. However, there is stil a lack of basic study on it. OBJECTIVE:To observe the effect of polytetrafluoroethylene artificial blood vessels on platelet aggregation and its cytocompatibility. METHODS:Effect on platelet aggregation:Dynamic platelet clotting time and plasma recalcification time were detected. Normal saline, distil ed water and polytetrafluoroethylene artificial blood vessels were added into the rabbit red cel suspensions, respectively, to count the hemolysis ratio. Cytocompatibility:Primary myocardial cel s from Sprague-Dawley rats were respectively seeded onto the common round coverslip and polytetrafluoroethylene artificial blood vessels, and the lactate deshydrogenase release and cel proliferation were detected at 3 and 5 days, respectively. RESULTS AND CONCLUSION:Polytetrafluoroethylene artificial blood vessels made no effects on the platelet clotting time and plasma recalcification time and 2.3%hemolysis ratio was observed. Compared with the common round coverslip, the myocardial cel proliferation and lactate deshydrogenase release showed no significant changes on the polytetrafluoroethylene artificial blood vessels. These results suggest that the polytetrafluoroethylene artificial blood vessel makes no effect on platelet aggregation and holds good hemocompatibility and cytocompatibility.
Keywords：PolytetrafluoroethyleneBlood Vessels ProsthesisPlatelet AggregationTissue Engineering
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 7064-7069 )