Therapeutic effect of porous tantalum implantation for osteonecrosis of the femoral head and construction of a prognostic model
Mao Zi-mu
Yin Kun
Wang Yu-ze
Li Peng-cui
Guo Li
Wei Xiao-chun
Abstract：BACKGROUND:Porous tantalum implantation is a novel treatment method for osteonecrosis of the femoral head (ONFH), but its therapeutic effect is under discussion. OBJECTIVE:To analyze the survival data of two kinds of porous tantalum implants for early-and mid-stage ONFH, and to determine the independent prognostic factors. METHODS:Thirty-four cases of ARCO stages I-III ONFH were enrol ed, and 25 patients (31 hips) were treated with porous tantalum implantation (simple group), and the other 9 patients (10 hips) treated with porous tantalum implantation combined with bone al ograft (combination group). Afterwards, the Harris scores and total survival rate of hips were recorded;the prognostic factors were analyzed by Cox regression. RESULTS AND CONCLUSION:The mean fol ow-up time in the simple and combination groups was (32.9 ±16.8) and (25.3±12.4) months respectively. The Harris scores at the last fol ow-up in the two groups were both higher than those before surgery, and moreover, the scores were higher in the simple group than the combination group (P<0.05). The total survival rate of hips significantly differed between groups (P=0.014). Cox regression showed that the history of hormone, accompanied with other chronic diseases, and adverse reactions made effects on the prognosis. These results suggest that porous tantalum implantation is an effective treatment method for ARCO stages I-III ONFH, and it can improve the functional recovery and survival rate of the hips.
Keywords：TantalumFemur Head NecrosisTissue Engineering
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 7043-7050 )