Mesenchymal stem cells in bone tissue engineering:osteogenic activity, immunogenicity, proangiogensis and osteogenesis
Chen Zhen-dong
Xu Fang-tian
Gao Hui
Abstract：BACKGROUND:It is stil a chal enge to repair bone defects caused by trauma, infection, tumor and congenital diseases. Bone tissue engineering is a promising method for bone defect repair showing important guiding significance in the clinic. OBJECTIVE:To review the progress of proliferation, osteogenic activity, immunogenicity, proangiogensis and in vivo osteogenic effect of mesenchymal stem cel s in bone tissue engineering. METHODS:The first author retrieved Wanfang and PubMed datebase for literatures published from 2008 to 2016, using the keywords of“mesenchymal stem cel , tissue engineering, osteogenesis, immune property, angiogenesis”in Chinese and English, respectively. Articles regarding mesenchymal stem cel s, tissue engineering, osteogenesis, immune property and angiogenesis were included, and repetitive and dated studies were excluded. Total y 1 772 articles were retrieved initial y, and in accordance with inclusion and exclusion criteria, 41 eligible articles were included for review analysis. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cel s and adipose-derived mesenchymal stem cel s are extensively applied in bone tissue engineering. Studies have shown that the osteogenic activity of bone marrow mesenchymal stem cel s is higher than that of adipose-derived mesenchymal stem cel s, but its immune regulation effect is weaker than that of adipose-derived mesenchymal stem cel s. Mesenchymal stem cel s hold remarkable immune regulation (immunosuppression and immune enhancement) and tissue repair capacity, which can eliminate inflammatory reactions at injured sites, promoting tissue repair. Adipose-derived mesenchymal stem cel s cultured under hypoxia environment can secret more angiogenic cytokines generating more vascular structures. Furthermore, increasing proof have confirmed that porous nano-polylactic acid combined with nano-carbon biological material can significantly promote the proliferation and osteogenesis of bone marrow mesenchymal stem cel s. Taking its tumorigenesis into consideration, mesenchymal stem cel s should be prudently used in the clinic.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 6956-6962 )