Broad-spectrum antibiotics prevent against early infection after hematopoietic stem cell transplantation

Duan Ling-xiao

doi:10.3969/j.issn.2095-4344.2016.45.017

Abstract：BACKGROUND:Occurrence of acute graft-versus-host disease after hematopoietic stem cel transplantation is closely related to early infection, so control ing infection can decrease the transplant-related mortality. <br> OBJECTIVE:To explore effects of broad-spectrum antibiotics on the occurrence of early infection after hematopoietic stem cel transplantation. <br> METHODS:Clinical data of 31 patients undergoing autologous peripheral blood stem cel transplantation were col ected. Within 30 days after cel transplantation, occurrence rate and types of early infection were detected and recorded. Besides, distribution of pathogens, as wel as treatment and outcome of patients were statistical y observed. <br> RESULTS AND CONCLUSION:All patients successfully underwent hematopoietic stem cell transplantation, and the occurrence rate of infection was 71%with no death at early stage after cell transplantation. Twenty strains of pathogens were detected, in which gram-negative bacteria accounted for 80%. In addition, there was a significant negative correlation between the number of neutrophils in the peripheral blood and the duration of infection (P<0.01). These results indicate that the infection rate at early stage after hematopoietic stem cell transplantation is relatively higher, which is associated with reduction and recovery time of neutrophils. Therefore, it is advisable to choose appropriate broad-spectrum antibiotics for preventive treatment at early stage after cell transplantation, so as to quickly and effectively control infections.