Local transplantation of human umbilical cord mesenchymal stem cells at different time after spinal cord injury in rats:a histological observation
Chen Sheng
Jin Zheng-shuai
Abstract：BACKGROUND:Spinal cord injury (SCI) is a disease causing a variety of motor and sensory dysfunctions, abnormal muscle tone and pathological reflex. Clinical y, human umbilical cord mesenchymal stem cel transplantation has become an employed therapy for SCI. <br> OBJECTIVE:To investigate the effect of local transplantation of human umbilical cord mesenchymal stem cel s in different time after spinal cord injury in rats. <br> METHODS:100 SPF male adult Sprague-Dawley rats were randomly divided into five groups:blank control group, SCI group, post-SCI 3-, 7-, 21-day transplantation groups (n=20 per group). Animal models of T10 SCI were made by Al en’s method in the latter four groups, and rats in the three transplantation groups were given HUCMSCs transplantation at 3, 7, 21 days after SCI, respectively. <br> RESULTS AND CONCLUSION:Compared with the SCI group, improved motor function scores, decreased interleukin-2 level, and increased serum interleukin-10 level were observed in the three transplantation groups at 49 days after modeling, indicating SCI was improved significantly in the three transplantation groups, especial y in the post-SCI 7-day transplantation group. These findings suggest that human umbilical cord mesenchymal stem cel transplantation for SCI repair improves the movement function of rats, and cel transplantation at 7 days after modeling has achieved best outcomes.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 6714-6719 )