Chitosan-gelatin spongeversusumbilical cord mesenchymal stem cellsfor skin wound healing
Fang Shao-xia
Guo Fen
Abstract：BACKGROUND:Umbilicalcord mesenchymal stem cels possess multipotent differentiation and self-replication abilities, and can differentiate into osteoblasts, chondrocytes, smooth muscle cels and vascular endothelial cels, which contribute to reepithelialization and angiogenesis.
<br> OBJECTIVE:To compare effects of umbilical cord mesenchymal stem cels and chitosan-gelatin sponge inskinwound healing.
<br> METHODS:Thirty male Sprague-Dawley rats were equivalently randomized into model, chitosan-gelatin sponge and stem cel groups. 3×3 cm ful-thickness skin defects were created on the rat dorsal area in each group, and 1 day later, model rats ineach groupwere given intradermal injection of PBS,chitosan gelorumbilical cord mesenchymal stem cels,respectively,for successive 15 days.
<br> RESULTS AND CONCLUSION:Compared with the model group, the wound healing rate was higher, the epidermal thickness was decreased, and the collagen fiber area was larger in the chitosan-gelatin sponge and stem cell groups. Furthermore, the healing effect in the chitosan-gelatin sponge group was superior to that in the stem cell group. To conclude, both chitosan-gelatin sponge and umbilical cord mesenchymal stem cells, especially umbilical cord mesenchymal stem cells,can effectively repair skin defects.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 5136-5141 )