Pelvic floor reconstruction using Gynemesh
Yang Lan
Wang Juan
Xu Lan-lan
Wang Li-feng
Li Yan-fang
Abstract：BACKGROUND:Gynemesh is a polypropylene fabricwovenby monofilament polypropyleneshaped into a flat form, with a strong tensile strength, smal foreign body reaction and good biocompatibility.
<br> OBJECTIVE:To investigate the effect of Gynemesh on pelvic floor reconstruction.
<br> METHODS:Gynemesh was prepared by the chemical reduction method in the liquid-phase, andobserved histologicaly.Then its thickness, elongation at break, tensile strength,andelasticity modulus were detected. Eight female New Zealand rabbits were used to make pelvic floor dysfunction models by a vaginal baloon, and randomly assigned into experimental group (pelvic floor reconstruction using Gynemesh) or control group (vaginal wal repair and hysterectomy), respectively. Thirty days post surgery, the Pelvic Floor Impact Questionnaire (PFIQ-7) and Pelvic Floor Distress Inventory (PFDI-20) were detected and compared between two groups.
<br> RESULTS AND CONCLUSION:The Gynemesh had a thickness of (0.37±0.14) mm, an elongation at break of (25.35±2.68)%, a tensile strength of (7.69±1.17) MPa, and an elastic modulus of (0.007±0.008) GPa. Under the light microscope, a large amount of pink colagen fibers arrangedneatlyon the Gynemesh, but no blue nuclear material and residual celsexisted. Under the scanning electron microscope, the fibers were tightly packed with no residual cels on the Gynemesh. At 30 days after surgery, the Gynemesh was not degraded and no erosion reaction occurred in the experimental group. Moreover, the experimental group had a lower incidence of complications compared with the control group (P< 0.05). These findings indicate that the Gynemesh hasgood biological performance and it is an ideal material for pelvic floor reconstruction.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 5116-5121 )