Biocompatibility of abioabsorbable material in the internalfixation of articular fractures
Xie Yang-jiang
Chen En-tao
Wu Bo
Ao Jun
Abstract：BACKGROUND:In recent years, poly-L-lactic acid (PLLA)/polylactic acid copolymer (PLGA)/hydroxyapatite (HAP) composite bioabsorbable material hasachived desired effectin articular fractures.
<br> OBJECTIVE:To investigate the biocompatibility of PLLA/PLGA/HA bioabsorbable material in the internal fixation of articular fractures.
<br> METHODS:In vivoexperiment: 22 New Zealand rabbits were enroled to prepare ankle fracture models, and were then randomly divided into two groups, including composite material group fixed with PLLA/PLGA/HA bioabsorbable material, and metal material group fixed with metal stent. Therapeutic effects and complications were observed at 7days after surgery.In vitroexperiment: PLLA/PLGA/HA bioabsorbable material was co-cultured with MG-63 cels to observe the cel proliferation and adhesion.
<br> RESULTS AND CONCLUSION:In thein vitroexperiment,nine rabbits healed wel, and two rabbits appeared to havecomplications in the mental material group; rabbits in the composite material group healed wel without any complications.In thein vitroexperiment:fusiform-shapedcelsaladhered to the compositestent after 1 day of incubation;the number of cels began to increase showing the strong growth ability,and in a tight and regular arrangementat 3 days after incubation; the cytotoxicity was grade 0 or 1 within 1-7 days of incubation.At 3 daysof co-culture, fusiform or polygonal cels appeared on the composite material,and these interconnectdecels extended wel, andmoreover,the frizz partson thecel surface grew into thecompositematerial, displaying a good adherence. To conclude, as a new bioabsorbable material, PLLA/PLGA/HAexhibits a good biocompatibility.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 5076-5081 )