Anovel plastic homogeneous bone repair material for sport-related articular cartilage injury

Ding Chen-guang; Fu Ping

doi:10.3969/j.issn.2095-4344.2016.34.003

Abstract：BACKGROUND:Currently, the components and preparation methodsof plastic bone repair materials remaincontroversial, andrare studies focus ontheirrepair effectsonsport-related articular cartilage injury. <br> OBJECTIVE:To analyze the effect ofanovel plastic homogeneous bone repair materialto repair sport-related articular cartilage injury. <br> METHODS:Thirty-six New Zealand rabbits were selected to prepare articular cartilage injury models,and wererandomized into two groups.Modelrabbits were repaired withthenovel plastic homogeneous bone material (acompositeof demineralized bone matrix and colagen) as experimental group, while the others repaired with sodium hyaluronate gel as control group. At 3 weeks after repair, treadmil system was utilized tostimulate sports training after athlete injury,for five consecutive sessions of 30 minutes each. At 16, 18 and 20 weeks after repair, the defect region was observedhistologicaly. <br> RESULTS AND CONCLUSION:At 16 weeks after repair, the defect region healedweland integrated with the surrounding tissues, and no significant inflammatory reaction appeared around the material in the experimental group;in the control group,afissureappeared at the defect regionbutwith no inflammatory reaction, and the material integrated with the interstitial site. At 18 weeks after repair, closely arranged acelular bone matrix could be found in the defect region, fibrous connective tissues were fewer, and there was a new bone formation around the edge of host bone in theexperimental group; the defect region healed, but new boneswerefewer in the control group. At 20 weeks after repair, the defect regionin the experimental groupwas filed with fibrous connective tissues,in whichthere were numerous new blood vessels,anda fewofnew tissuesappearedaround the edge of host bone; the defect regionin the control groupwas improvedandno neovascularizationoccurred. These findings suggest thatthenovel plastic homogeneous bone material can promote the repair of sport-related articular cartilage injury withless rejection reactions.