Changes in serum biomarkers of bone metabolism, Chemerin and hypoxia-inducible factor 1alpha in elderly men living on the plateau
Chen Liang
Xi Ai-qi
A Xiang-ren
Li Zi-an
Xi Kun
Peng Hai
Li Cheng-xiong
Wang Liang
Li Xiang
Abstract：BACKGROUND:Increasing evidence suggests that the effects of hypoxia on the formation of osteoblasts are influenced by oxygen concentration and action time of hypoxia. However, very little is known regarding the changes in serum biomarkers of bone metabolism, Chemerin (an adipocyte-derived factor) and hypoxia-inducible factor 1αin elderly men living on the plateau. OBJECTIVE:To investigate the changes in serum biomarkers of bone metabolism, Chemerin and hypoxia-inducible factor 1α, and to analyze the correlation of them in elderly men living on the plateau. METHODS:A total of 162 Chinese Han elderly men living on the plateau were included and divided into 1 980 m group (n=83) and 3 300 m group (n=79). Levels of bone-specific alkaline phosphatase, tartrate-resistant acid phosphatase 5b, Chemerin, and hypoxia-inducible factor 1αin peripheral blood serum were determined by enzyme-linked immunosorbent assay. RESULTS AND CONCLUSION:Serum levels of Chemerin and hypoxia-inducible factor 1αwere significantly decreased (P<0.05), while serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b were significantly increased (P<0.05) in the 1 980 m group compared with the 3 300 m group. Serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b were negatively correlated with Chemerin and hypoxia-inducible factor 1α(P<0.01). Our results suggest that hypoxia affects bone metabolism, Chemerin and hypoxia-inducible factor 1αin elderly men living on the plateau.
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Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 4876-4882 )