Insulin-like factor, testosterone and bone metabolism indexes in the prediction of osteoporotic fractures in elderly men

Liu Xuan-min

doi:10.3969/j.issn.2095-4344.2015.24.002

Abstract：BACKGROUND:The domestic incidence of osteoporosis in elderly men has an increasing trend with aging. Osteoporosis patients are prone to fracture, which can pose a serious threat to patient’s life and safty, but there is stil a lack of effective screening measures to prevent its occurrence. OBJECTIVE:To explore the clinical significance of insulin-like factor, testosterone and bone metabolism index levels in the prediction of osteoporotic fracture in elderly men. METHODS:Total y 120 male patients with osteoporotic fractures were enrol ed as observation group, and another 120 healthy males with no osteoporosis admitted at the same period acted as controls. There were no differences in age and body mass index between the two groups. Insulin-like factor, testosterone and bone metabolism index levels were detected and compared between the two groups. RESULTS AND CONCLUSION:Compared with the control group, the bone mineral densities of the lumbar vertebrae and left femoral neck were significantly lower in the observation group (P<0.05), and the levels of insulin-like factor and serum testosterone were also significantly lower in the observation group (P<0.05), but the levels of col agen type I C-terminal foreign bodies andβ-CTX were significantly higher in the observation group. No significance was found in the osteocalcin, serum calcium, serum phosphorus levels between the two groups (P>0.05). These findings suggest that the serum testosterone, insulin-like factor and some bone metabolism indexes can be used for prediction of osteoporotic fractures in elderly men, which have a certain reference value.