Three kinds of heterogeneous bone materials for repair of periodontal bone defects

Dong Hong-bin; Zhang Qin; He Hui-yu; Keyimu Kelimu; Wang Huan-huan

doi:10.3969/j.issn.2095-4344

Abstract：BACKGROUND:Currently, the treatment methods for periodontal disease mainly include autogenous bone graft, bone alograft, bone xenograft, and bone substitute implantation, and each method has its own merits and demerits. OBJECTIVE:To compare the effects of calcined bone, freeze-dried bone and Bio-oss bone used alone on the repair of periodontal bone defects. METHODS: A total of 36 healthy rabbits were randomly divided into four groups, and unilateral periodontal tissue defect model was established in each group. These four groups were respectively treated with calcined bone, freeze-dried bone and Bio-oss bone, and nothing (blank control group). After 4, 8 and 12 weeks, animals were sacrificed respectively for a complete specimen used in gross, X-ray and histological observations. RESULTS AND CONCLUSION:Compared with the blank control group, the bone density, new cementum height, new alveolar height and new periodontal ligament height were al higher in the calcined bone, freeze-dried bone and Bio-oss bone groups at 4, 8, 12 weeks after treatment. As time went on, defected bone tissues gradualy became continuous, newborn periodontal tissues were visible on the root surface and gradualy became mature and increased in number. At 4 weeks after treatment, the new alveolar bone height was higher in the calcined <br> bone group than the freeze-dried bone group (P < 0.05); at 12 weeks after treatment, the new periodontal ligament height was significantly higher in the freeze-dried bone group than the calcined bone group and Bio-oss bone group (P < 0.05). These results show that the calcined bone is superior to the freeze-dried bone and Bio-oss bone in terms of osteogenic induction, but the freeze-dried bone is better than the calcined bone and Bio-oss bone to promote the periodontal ligament regeneration.