Double effects of Chemerin on inflammation and metabolic syndrome
Li Xue-mei
Zhai Li-dong
Abstract：BACKGROUND:In recent years, a number of clinical and basic studies have shown that Chemerin is closely associated with the metabolic syndrome.
<br> OBJECTIVE:Through the review of Chemerin’s role and mechanism in inflammation and obesity, hypertension and lipid metabolism, to summarize the relationship of Chemerin with inflammatory and metabolic syndrome.
<br> METHODS:Literatures about Chemerin were retrieved in PubMed database and Wanfang database by the first author from 1990 to 2014. Systematic col ation, summary and analysis were performed.
<br> RESULTS AND CONCLUSION:The Chemerin level is associated with body fat content, energy metabolism and inflammation. Chemerin plays an important role in the pathophysiology of obesity and metabolic syndrome. Due to the dual role of Chemerin in inflammation and in metabolism, it may become a key factor linking chronic inflammation, obesity and related diseases. Under different inflammatory states, Chemerin plays different roles, which may be related to different cleavage ways under different inflammatory environments, but Chemerin has no explicit effects in obesity and metabolic syndrome. Further research is needed for the clear relationship of serum levels of Chemerin with obesity and metabolic syndrome.
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Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1094-1098 )